The dose depends on your ailment, different medications/food varieties you might be taking, and reaction to treatment. To lessen your gamble for serious incidental effects, don't expand your portion, take it all the more oftentimes, or require it for a more drawn out investment than coordinated by your PCP. Serious incidental effects might happen even at regular endorsed dosages. Assuming your primary care physician guides you to take colchicine consistently, use it routinely to get the most advantage from it. To assist you with recalling, take it at the equivalent time(s) every day. Abstain from eating grapefruit or drinking grapefruit juice while utilizing this medicine except if your PCP or drug specialist says you might do so securely. Grapefruit can expand the opportunity of incidental effects with this medication. Ask your PCP or drug specialist for additional subtleties. Assuming you are taking this drug to get side effects due familial Mediterranean fever, let your primary care physician know if your condition doesn't improve or on the other hand on the off chance that it declines.