These medications can cause comparable secondary effects. However, not at all like hydrocodone, Percocet could likewise cause liver harm in uncommon cases, because of its acetaminophen content. To figure out more about how these medications analyze, talk with your PCP. They can assist you with deciding your best treatment choice, in light of the idea of your aggravation. Indeed, you can normally take hydrocodone with ibuprofen. These medications don't associate with one another or cause comparable secondary effects, so they're typically protected to take together. As a matter of fact, this mix of medications can be useful in the event that you have irritation (expanding and harm) related with your aggravation. Ibuprofen is a sort of pain killer called a nonsteroidal mitigating drug (NSAID). It decreases aggravation as well as torment. If you have any desire to take hydrocodone with ibuprofen, talk with your primary care physician about whether this blend is appropriate for you. Hydrocodone has boxed warningsTrusted Source. Boxed admonitions are the most serious alerts from the Food and Medication Organization (FDA). They ready specialists and patients about drug impacts that might be perilous. Hydrocodone's boxed admonitions include: Dangers of abuse or habit. Hydrocodone has a gamble of abuse. This is the point at which a medication is taken as it were or for an explanation other than how it's endorsed. It likewise has a gamble of enslavement, which is the point at which a medication is taken regardless of whether it's causing unsafe impacts.