Cancer, a formidable adversary, continues to challenge researchers and clinicians worldwide. In the quest for effective treatments and cures, scientists have turned to a fascinating tool in their arsenal: xenograft models. These models have played a pivotal role in advancing our understanding of cancer and testing potential therapies. In this beginner's guide, we will delve into the world of xenograft model, demystifying their significance in cancer research, their types, and how they contribute to the fight against this relentless disease.