In the wave of sustainable development of modern agriculture, the design and optimization of organic fertilizer granulation production line has become a key link to improve agricultural production efficiency and promote resource recycling. The design and optimization of Organic Fertilizer Granulator Production Line is a systematic project, which needs to consider raw material characteristics, production requirements, equipment performance and the application of intelligent and automated technology. Through scientific and reasonable planning and layout, an efficient, intelligent and environmentally friendly organic fertilizer production system can be created to contribute to the sustainable development of agriculture.