Availability of the reference human genome sequence enabled the generation of oligonucleotide probes and short sequence markers (SNPs) mapped to specific chromosome positions that could then be used to generate microarray platforms to analyze micro biome sequencing from specific patients to search for genomic copy number variants and genomic structural variants. Polymorphic SNP markers also facilitated analysis of segregation of specific genomic regions in families and analysis of inheritance of specific genomic regions.
Posted on 01/21/21
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