Malegra FXT is a combination medication used to treat both erectile dysfunction (ED) and premature ejaculation (PE) in men. It combines two active ingredients: sildenafil citrate (a phosphodiesterase type 5 inhibitor) and fluoxetine (a selective serotonin reuptake inhibitor). It is typically taken about 30 to 60 minutes before engaging in sexual activity. The medication is usually effective during this time frame.