While Malegra 50 mg can be a cost-effective alternative to Sildenafil, it offers similar effectiveness in treating ED. However, it’s important to consult a healthcare provider before starting treatment, as individual responses and potential side effects can vary. Like Sildenafil, Malegra 50 mg works by inhibiting the enzyme PDE5. This leads to the relaxation of smooth muscle in the blood vessels, particularly in the penis, allowing increased blood flow when sexually stimulated, leading to an erection.